The neuronal calcium-sensor proteins
نویسندگان
چکیده
منابع مشابه
The neuronal calcium sensor family of Ca2+-binding proteins.
Ca(2+) plays a central role in the function of neurons as the trigger for neurotransmitter release, and many aspects of neuronal activity, from rapid modulation to changes in gene expression, are controlled by Ca(2+). These actions of Ca(2+) must be mediated by Ca(2+)-binding proteins, including calmodulin, which is involved in Ca(2+) regulation, not only in neurons, but in most other cell type...
متن کاملNeuronal Calcium Sensor Proteins – Recognizing a Face in a Crowd
Received: 02 March 2012; accepted: 18 March 2012; published online: 02 April 2012. Citation: Kretsinger RH (2012) Neuronal calcium sensor proteins – recognizing a face in a crowd. Front. Mol. Neurosci. 5:41. doi: 10.3389/fnmol.2012.00041 Copyright © 2012 Kretsinger. This is an open-access article distributed under the terms of the Creative Commons Attribution Non Commercial License, which permi...
متن کاملMolecular structure and target recognition of neuronal calcium sensor proteins
BACKGROUND Neuronal calcium sensor (NCS) proteins, a sub-branch of the calmodulin superfamily, are expressed in the brain and retina where they transduce calcium signals and are genetically linked to degenerative diseases. The amino acid sequences of NCS proteins are highly conserved but their physiological functions are quite distinct. Retinal recoverin and guanylate cyclase activating protein...
متن کاملThe diversity of calcium sensor proteins in the regulation of neuronal function.
Calcium signaling in neurons as in other cell types mediates changes in gene expression, cell growth, development, survival, and cell death. However, neuronal Ca(2+) signaling processes have become adapted to modulate the function of other important pathways including axon outgrowth and changes in synaptic strength. Ca(2+) plays a key role as the trigger for fast neurotransmitter release. The u...
متن کاملNeuronal calcium sensor proteins are direct targets of the insulinotropic agent repaglinide.
The NCS (neuronal calcium sensor) proteins, including neurocalcins, recoverins and visinin-like proteins are members of a family of Ca2+-sensitive regulators, each with three Ca2+-binding EF-hand motifs. In plants, lily CCaMK [chimaeric Ca2+/CaM (calmodulin)-dependent protein kinase] and its PpCaMK ( Physcomitrella patens CCaMK) homologue are characterized by a visinin-like domain with three EF...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
سال: 2004
ISSN: 0167-4889
DOI: 10.1016/j.bbamcr.2004.08.008